Is it possible to end the Newtonian division of philosophy and science, as a result of which philosophy has nothing to do and science is hiding its own assumptions?
For a panpsychist research program there is roughly the challenge of how to get from facts about the consciousness of particles to facts about human or animal consciousness.
The science could reveal or at least approximate timeless objective truths about the universe and our place in it or is it a social construction and should not be granted the status of final arbiter of ultimate truth?
The effectiveness of mathematics as applied to describing physics isn't unreasonable and there is a quite natural back-and-forth between mathematics and the natural sciences.
About the overwhelming evolutionary limitations of our senses and minds, and how scientific theories and instruments help us to get closer to reality.
A central plank of critical realism is that science can no longer be considered as just another myth or story.